If dosing is interrupted for 3 days or fewer, restart Severe Alzheimer's disease is 13.3 mg/24 hours administered once per day
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The effective dosage of EXELON PATCH in patients with Or 13.3 mg/24 hours administered once per day replace with a new patch every The effective dosage of EXELON PATCH is 9.5 mg/24 hours
Mild to Moderate Alzheimer's Disease and Mild to Moderate Incidence of adverse reactions [see WARNINGS AND PRECAUTIONS, ADVERSE No appreciable additional benefit, and are associated with an increase in the Doses higher than 13.3 mg/24 hours confer For patients with severeĪD, 13.3 mg/24 hours is the effective dose. The maximum effective dose of 13.3 mg/24 hours dose. Moderate AD and PDD patients, continue the effective dose of 9.5 mg/24 hoursįor as long as therapeutic benefit persists. Previous dose, and only if the previous dose has been tolerated. Increase the dose only after a minimum of 4 weeks at the
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Initiate treatment with one 4.6 mg/24 hours EXELON PATCHĪpplied to the skin once daily. DOSAGE AND ADMINISTRATION Recommended Dosing Initial Dose Moderate dementia associated with Parkinson's disease (PDD). Parkinson's Disease DementiaĮXELON PATCH is indicated for the treatment of mild to Mild, moderate, and severe Alzheimer's disease. Efficacy has been demonstrated in patients with
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With free coupon View Coupon INDICATIONS Alzheimer's DiseaseĮXELON PATCH is indicated for the treatment of dementia Layer 4: Release Liner (removed at time of use)Įxcipients within the formulation include acrylic copolymer, poly(butylmethacrylate, methylmethacrylate), silicone adhesive applied to a flexible polymer backing film, silicone oil, and vitamin E. The release liner is removed and discarded prior to use.įigure 1: Cross Section of the EXELON PATCH The patch is a 4-layer laminate containing the backing layer, drug matrix, adhesive matrix and overlapping release liner (see Figure 1). The distribution coefficient at 37☌ in n-octanol/phosphate buffer solution pH 7 is 4.27.ĮXELON PATCH is for transdermal administration. Rivastigmine is a viscous, clear, and colorless to yellow to very slightly brown liquid that is sparingly soluble in water and very soluble in ethanol, acetonitrile, n-octanol and ethyl acetate. It has an empirical formula of C 14H 22N 2O 2 as the base and a molecular weight of 250.34 (as the base). DESCRIPTIONĮXELON PATCH (rivastigmine transdermal system) contains rivastigmine, a reversible cholinesterase inhibitor known chemically as (S)-3-phenyl ethylmethylcarbamate. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Exelon Patch. Tell the doctor if you have any side effect that bothers you or that does not go away. The most common side effects of Exelon Patch include: Get medical help right away, if you have any of the symptoms listed above.
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